Phenibut

The Anti-Anxiety Nootropic

Dose

In studies it has been used between 500 mg and 1 g per day.

Benefits

• Significantly reduce anxiety

• increase attention and concentration

• recreationally to calm nerves in social situations

• It induces calm feelings and focus without the upper effects of caffeine or the depressive effects of alcohol.

• increase cognitive function

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About

Phenibut was originally developed in the 1960s in Russia. Since then it has been clinically used to relieve tension, fear, anxiety, posttraumatic stress disorder, depression, and insomnia. Furthermore, it has also been used to enhance intellectual function in various mental disorders. These approved uses are currently only available in Russia.

Mechanism of Action

Phenibut (beta-phenyl-GABA) is a synthetic drug, with similar effects to the neurotransmitter GABA. It's mechanism of action includes boosting GABA activity in the brain and stimulating dopamine and serotonin neurotransmission. These 3 crucial neurotransmitters, GABA, serotonin and dopamine, phenibut greatly increases cognitive ability, mood and energy.

Side Effects

Cannot be mixed with alcohol. Doses surpassing 1 gram are considered unsafe. Should not be used everyday.

In Studies

Cognitive Decline

276 patients with cognitive disorders were given Aniracetam and observed for 6 months, with tests given at 3,6 and 12 months. Patients were found to experience heightened emotional states and improved motor function within 3 months. an overall boost of cognitive performance was experienced by 6 months. This improvement continued to be observed into the 12 month test. Furthermore, they found a positive effect on emotional stability in patients with dementia.

Koliaki C.C., Messini C., Tsolaki M. “Clinical Efficacy of Aniracetam, Either as Monotherapy or Combined with Cholinesterase Inhibitors, in Patients with Cognitive Impairment: A Comparative Open Study” CNS Neuroscience & Therapeutics Volume 18, Issue 4, pages 302–312, April 2012

Anti Depressant and Learning Enhancement

Nakamura et al., 2001, found that aniracetam could act as a potent anti-depressant treatment in the case of age-related cognitive decline, by stimulating the release of dopamine. In other study by Cumin et al., 1982, researchers found learning and memory enhancement associated with aniracetam use. They placed rats and mice through 6 different scenarios, including drug induced memory loss or electric shock avoidance. Regardless of the scenario, Aniracetam supplementation was shown to significantly improve cognitive functions.

Nakamura K, Tanaka Y. “Antidepressant-like effects of aniracetam in aged rats and its mode of action.” Psychopharmacology (Berlin). 2001 Nov;158(2):205-12.

Cumin R., Bandle E.F., Gamzu E., Haefely W.E. “Effects of the novel compound aniracetam (Ro 13-5057) upon impaired learning and memory in rodents.” Psychopharmacology (Berlin) 1982;78(2):104-11.

Fetal Alcohol Syndrome

Aniracetam was found to have a positive effect on fetal alcohol syndrome. Wijayardhane et al., showed that aniracetam could be used to repair damage to synaptic transmission in the brain. The study exposed pregnant Sprague-Dawley rats to ethanol and a saccharin-like sweetener. Similar to babies born to alcoholic mothers, rat pups born to these female rats would be extremely cognitively impaired. To compare the effect of aniracetam to the placebo the rat pups born with Fetal Alcohol Syndrome were treated with aniracetam at 18 and 27 days after birth. The results found that Aniracetam completely restored synaptic transmissions in their brains while reversing any cognitive deficits associated with fetal alcohol syndrome.

Wijayawardhane .1, Shonesy B.C., Vaglenova J., Vaithianathan T., Carpenter M., Breese C.R., Dityatev A., Suppiramaniam V. “Postnatal aniracetam treatment improves prenatal ethanol induced attenuation of AMPA receptor-mediated synaptic transmission.” Neurobiology of Disease 2007 Jun;26(3):696-706

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